I've been using ORK a couple of months now with increasingly frequent usage as of late. Each time I figure out something new. Now that's partly because I didn't go through every step of the tutorials and partly because ORK is truly comprehensive as stated above.
I think the "RPG Maker on steroids" is putting it lightly. In fact, I think its capabilities are quite beyond a degree of simple explanation. Different users will discover those capabilities in different ways as they approach their games in their own manner.
The thing with RPG Maker and other genre-specific engines is your game will most likely exist within the confines of that application exclusively. While Yanfly has written an ungodly amount of scripts that took RPG Maker far beyond what its creators imagined, everything is still within the confines of RPG Maker if you get what I'm saying.
I think a good analogy is that RPG Maker would be like a customized car. You can change the color, interior, add some custom parts, etc. but you have the original engine, frame, etc. always. ORK is a (hot rod) engine, transmission, axle, brakes, electronics, etc. You add the rest to build whatever vehicle you want. Yes, that will take some welding and time but you'll have a pretty sweet ride in the end.
Because it's a framework, ORK works with pretty much everything else in Unity. I don't think I've run across anything it conflicts with. You can basically make a scene with two cubes, add ORK and you have a RPG as simple or complex as you want that's based on two cubes. Got a sprawling 3D environment of a city? Add ORK and you've got an entire city now you can turn into an RPG as you populate it.
It has a visual node-based system for complex or simple events and dialogue that covers pretty much everything but I see that you want a very story-driven game. I'm using Dialogue System and Love/Hate assets from Pixel Crushers. They offer very extensive NPC relationships based on emotions, interactions, gossip, deeds, etc. Both can combine with ORK through provided bridges to provide super rich story and interaction options.
I can't say I have 2D experience yet with it but for everything in my experience so far, ORK is superb. I'd have to say it's the most powerful comprehensive asset I've come across yet.