ORK will mostly handle this for you based on your setup.
The basic setup is handled in Game > Game Settings, where you'll find the Screen/GUI Settings right at the top. Here you'll define the default screen size that all your UI in ORK is designed for, and the GUI Scale Mode handles how it'll be scaled to other resolutions - the default should be Scale To Fit which usually gives a pretty good result.
If you're dealing with different screen formats, e.g. 4:3, 16:9, 16:10, etc., you can use Own GUI Scale settings of GUI layers (Menus > GUI Layers) to e.g. anchor them to different corners of the screen via the GUI Anchor setting. This e.g. allows you to have your HUDs and menus move with the corner they're anchored to (via their GUI layer).