Short step-by-step:
1) Create a shortcut prefab using the scene hierarchy context menu: ORK Framework > HUD > Shortcuts > Shortcut Content (for prefabs)
Use one of the variants, depending on which additional content you want, e.g. slot index.
Make a prefab out of the created game object, it'll be used to create the individual shortcuts (abilities, items, etc.) in a slot.
2) Navigate to UI > Shortcut Settings and use the prefab as the Default Shortcut UI, i.e. it'll be used by all shortcuts as default version.
3) Create a shortcut slot prefab using the context menu: ORK Framework > HUD > Shortcuts > Shortcut Slot Content (for prefabs)
The UI Key settings define which shortcut UI it'll use to create a shortcut on it's slot. You can also set up how the slot's content can be used and assigned, as well as state changes (e.g. highlight color when it's active, etc.). You can also add an Image component for a background image of the slot.
Make a prefab out of the created game object, it'll be used by a shortcut slot list to create the individual slots.
4) Create a HUD as usual, e.g. a horizontal one via the context menu: Makinom > HUD > HUD (Horizontal Layout)
Add a Shortcut Slot List component to it that uses the shortcut slot prefab (created in #3). The component also defines which slots are displayed.
Make a prefab out of the HUD and set up the HUD in ORK as usual.